The teenage son of a former friend hires her to defend him in a murder case, Alicia makes a difficult journey back to her old life.
As the FBI pursues "the man in the suit," Reese is even more determined to protect the latest person of interest after learning she is the sister of a soldier who was killed in action.
When the team treats a 6-year-old with multiple health issues, they must collaborate with her mother (Jessica Collins), who is also a doctor; Wilson and House go on vacation.