Tension arises between Derek and Meredith's mother; Cristina is mesmerized by the lifestyle of working in the dermatology wing.
Amanda takes her search for her father's identity to a higher source and Betty goads Daniel into changing Mode's message.
Wolowitz struggles with moving out of his mother’s house. Meanwhile, Sheldon is caught in the middle of an argument between Amy and Wil Wheaton.
A bakery owner meets an unsavoury demise and it's up to Federico to put the pieces back together. Nate decides not to sell to Kroehner, and Claire finds a way to pay back Gabe for blabbing about her toe-sucking exploits.
A woman's strangulation appears to be the work of a cross-dresser; Licalsi's new partner tries to pick a fight with Kelly.