After several of Bailey's patients die, she becomes the focus of a CDC investigation; Cristina teases Alex about his feelings for Jo; Owen continues to take care of Ethan while his parents remain in the hospital.
Castle is captured and forced to work with strangers to solve deranged puzzles and mind games, while Beckett and the 12th precinct must race against time to rescue Castle and catch a killer.
The investigation into the death of a woman's husband reveals that the deceased man was living a double life.
The death of a woman found mummified in a wine cellar is investigated, while a recuperating Jane receives devastating news.
Korsak tries to help an old friend fulfil his dying wish, to finally solve the deaths of his wife and daughter in a house fire some 15 years earlier.