After several of Bailey's patients die, she becomes the focus of a CDC investigation; Cristina teases Alex about his feelings for Jo; Owen continues to take care of Ethan while his parents remain in the hospital.
Castle is captured and forced to work with strangers to solve deranged puzzles and mind games, while Beckett and the 12th precinct must race against time to rescue Castle and catch a killer.
The investigation into the death of a woman's husband reveals that the deceased man was living a double life.
Pete and Violet go to a marriage counselor; Amelia gets some devastating news; Mason refuses to speak to Charlotte and Cooper; Violet suspects the sister of one of her patients.
The squad is forced to work with a private investigator when a clothing designer is found poisoned and his wife reported missing; Jane asks Maura to teach her mother how to handle her finances.