The team tries to end a standoff at a hospital between gang members and a man trying to protect his injured brother.

Eric and the Crisis Resolution team negotiate a pay-off after the murder of a man and threats from the killer to kill the man's wife.

Following the assassination of a suspect, Clarice and VICAP are investigated by Krendler's rival at the Bureau; when Ardelia is recruited to assist him, it causes friction between the two friends.

Andy's romance with Callaghan becomes complicated when they disagree over how to handle a witness in a murder case; the other rookies discover the shocking truth behind evidence from a fatal traffic collision.

When the River Murders are linked to a pharmaceutical company, Clarice seeks help from their corporate accountant; Catherine steps outside for the first time since her rescue.

Clarice and Ardelia team up to investigate a twisted cold case after the body of a missing teenager is found entombed in concrete; Clarice wrestles with the knowledge that Krendler may know the man who attacked her.

ViCAP investigates what appears to be the suicide of a medical student; Krendler secretly collects a DNA sample from the man he suspects attacked Clarice.

Catherine Martin escapes to Carneys Point, New Jersey, in order to confront Buffalo Bill's mother; Clarice volunteers to be the one to find Catherine before she commits a vile act.

Clarice closes in on the entity behind the River Murders, Alastor Pharmaceuticals; the team race to Alastor to prevent the purging of any incriminating evidence; Clarice questions the CEO.

Bo leads her friends into battle ahead of schedule when her hand is forced by the enemy, but the deceit of one of her allies threatens the mission.

Thony must team up with Arman and Nadia in a new money-making venture to save Luca's life; Fiona works to keep Chris out of trouble when the threat of evidence arises.

Arman and Nadia start to realise Thony's ethical methods aren't making them enough money; Fiona takes the lead on starting her and Thony's new cleaning business; Garrett is one step closer to solving the Cortés case.

After Fiona puts herself in a dangerous situation, Thony resorts to calling Arman for help; Garrett works to get put back on the Cortés case; Chris struggles with the emotional aftermath of recent events.

An unexpected trio emerges in the mission to take down Cortés; Arman and Nadia's relationship hits a breaking point; Fiona attempts to keep her family safe; Chris continues to grieve.

Kelly and Sam pursue different leads to exonerate an innocent teen accused of shooting their colleague. Both investigations wind up informing the Coyote case in an unexpected way.

Naz gets in deeper with the Coyotes, earning him an invite to Adeline's party. When he finds himself in hot water, it's up to Sam and Kelly to pull him out before events get deadly.

When a school bus full of kids goes missing Jack and the team suspect two trouble-making students. Samantha copes with the physical and emotional aftermath of her recent gunshot wound and Jack attempts a reconciliation with his estranged wife and two young daughters.