As the temporal facility gets closer to destruction, Cole travels to 1957 to save humanity, while everyone else looks for Titan, the stronghold of the Witness.
Scattered all across the galaxy, the team are struggling. They must work to find their footing after losing Coulson.
After finding themselves in yet another gambling dilemma, a mysterious stranger offers Enoch and FitzSimmons a ride home.
Yo-Yo and Keller move forward with their relationship; parasitic aliens threaten the human race; Deke makes a startling discovery.
The reason for Sarge's arrival on Earth is revealed. Fitz and Simmons remain imprisoned in space.