The death of a first-class passenger on a flight to Las Vegas has Grissom and his team scrambling to examine the physical evidence and get testimony from the other passengers.
Weaver introduces Greene to Dr Gabriel Lawrence, a physician reputed to be a founding father of emergency medicine, but Greene immediately dislikes him and they argue about ordering a test for a patient.
Denny Crane's long-lost son (Freddie Prinze Jr.) resurfaces as the lawyer representing environmental interests against a shopping mall development planned by one of the firm's biggest clients.
Alan again defends Denny, who has been arrested for illegally shipping human fat out of the country; Clarence tries his first case, a homicide, with Bethany and Paul's help; a member of the firm bids farewell.
Nate muses on the loss of his first love; Claire finds a temporary financial solution while waiting for a grant; Brenda takes a break for some fun.