Something's afoot in Rapid City when the BAU find ritualistic marks on bodies dumped on an American Indian reservation and Reid gives the team cause for concern.
Cooper and the Red Cell team attempt to stop a killer who takes the time to disfigure his victims' faces.
An unidentified woman is found dead in an alley; Nate's little sister goes missing and secrets from his past unfurl.
FBI agents Mark Benford and Demetri Noh investigate when everyone on Earth blacks out for exactly two minutes and seventeen seconds, during which they receive glimpses of their futures six months in advance.
Henry's surprise birthday celebration turns into a disaster when a dead body is discovered in a shut-down barbecue joint. Elsewhere, Ray realises that "Dr Jekyll" is back and he has moved on to live victims.