Maura and Jane investigate when a bride is killed just hours before her wedding.
Isaiah joins Sadie on a trip to visit her prison in prison. Meanwhile, Albert and Cameron defend a transwoman, and Cameron gives in to her feelings.
When a woman is swallowed whole by a giant snake, the team suspect that Horatio's nemesis, Clavo Cruz, is behind an operation that uses snakes to smuggle drugs into the country.
An undercover police officer who is investigating the Mob is held captive and the Behavioral Analysis Unit believes a serial killer is responsible.
While on the hunt for the victim of a kidnapping who is being held for ransom, the team uncover a connection to the Russian mob.