After a global pandemic destroys civilisation, a hardened survivor takes charge of a 14-year-old girl who may be humanity's last hope.

In 2003, a scientist makes a devastating discovery. In 2023, now outside of the quarantine zone, Joel and Tess clash over Ellie's fate as they navigate a long-abandoned Boston.

After a harrowing trek across a desolate United States, Joel and Ellie find themselves navigating dangerous Kansas City on foot. Later, rebel leader Kathleen instigates a manhunt.

On the streets of a newly free Kansas City, Henry fights to protect his brother Sam from rebel soldiers who will stop at nothing to appease their ruthless leader.

After months of traveling, Joel and Ellie receive a grave warning about what lies ahead. Later, Ellie learns more about Joel's past - while Joel tries his best to forget.