In a Bolivian jungle, Adam and Caveman Rob pursue the fabled Executioner Wasp, Warrior Wasp, and Goliath Bird-Eating Tarantula. One causes a medical emergency, and another delivers a nightmarish bite that leaves Adam's arm partially paralysed.

Adam and Caveman Rob head to South Africa to face the giant Bark Scorpion, the tiny Uroplectes Scorpion, and the highly venomous Lion Fish.

In Mexico, Adam and Caveman Rob tango with two torturous animals, including one that topped Justin Schmidt's pain scale; the guys up the stakes by covering their hands with hundreds of Harvester ants and two Pain Index records are shattered.

In Africa, Adam and Caveman Rob search for the Nile Monitor Lizard and the Velvet Ant, but are attacked by an even deadlier animal and are lucky to escape with their lives. The guys experience a brutal bite that makes them question their mission.

A dangerous underwater hunt for the potentially deadly Scorpion Fish in the Baja California ocean leads to a toxic sting that puts Adam in danger, and matches the highest pain score to date.

Adam and Caveman Rob journey to the Asian island of Bali and face off with the fire urchin that almost knocks out Caveman Rob, and the rove beetle that surpasses the record for the highest pain score to date and causes permanent damage.