Derek finds an old diary of Meredith's mother; Callie anxiously prepares for her first real date with Erica; Cristina stumbles into a part of the hospital that she and the other residents have never seen.
Pressured by Bernadette, Howard comes to terms with moving out of his mother’s house. Meanwhile, Sheldon, who’s caught in the middle of a feud between his “girlfriend” Amy and good friend WIL WHEATON, goes to Penny for advice. Star Trek’s LeVAR BURTON guest stars.
When Justin and his classmates visit Mode, Betty is bothered by the message the magazine is sending across to the kids and encourages Daniel to use ordinary women as models during fashion week. Meanwhile, Amanda visits a psychic for news about her biological father and Wilhelmina gets an unprecedented turnout in her latest plan for absolute power.
A woman's strangulation appears to be the work of a cross-dresser; Licalsi's new partner tries to pick a fight with Kelly.