Despite being scattered all across the galaxy, the team struggle to work to find its footing after losing Coulson.
Fitz and Enoch struggle in space, while Sarge and his team move forward to carry out a mysterious mission on Earth.
Yo-Yo and Keller take things public and parasitic aliens threaten the human race. Meanwhile, someone really needs boba.
Sarge has May, Altarah has Daisy, Enoch and Simmons and now, there are two planets that need saving. Meanwhile, in space, Enoch admits to Fitz that his involvement in the capture of Simmons, which greatly angers Fitz before he is incapacitated.
To face The Galaxy-Hopping Hate-Beast That Eats Planets, the team on Earth asks for help in all the wrong places. Meanwhile, back on the Lazy Comet, something weird goes on with Izel's crew.