Lincoln Burrows awaits his fate on death row while his brother Michael Scofield, a structural engineer convinced of Lincoln's innocence, gets himself incarcerated as well in the hope of freeing his brother from the inside.
Michael, Lincoln and the inmates risk life and limb, the Vice President fears she will lose her command if not her life, and Veronica tracks down the most significant piece of evidence to prove Lincoln's innocence.
Sara considers whether she should help Michael with his plan, Michael betrays Warden Pope, and Veronica finds evidence that points her to Montana, but realises that her closest ally may actually be her greatest enemy.
Westmoreland takes drastic action to prevent Bellick from unravelling their plans forcing the inmates to speed up their escape, Michael begs Sara to help him, and Veronica is betrayed by Nick.
Tensions mount after Lincoln warns Michael that someone in the group will have to remain behind, Michael makes progress in reaching the infirmary, and Abruzzi threatens to kill T-Bag if he doesn't drop out of the group.