Izzie's medical condition requires a difficult surgery; one of Owen's PTSD episodes causes Cristina to be injured.
Stillman asks Rush and Valens to reopen the 1980 case of an 8-year-old boy found buried in a snowdrift.
The parents of a missing college student seek help; David gets help on the Cytron case from an unexpected source; Mellie proves her political prowess.
Castle finds himself vying with an FBI agent for Beckett's attention when she is called in to help the agency investigate a little girl's disappearance from her home.
Sean tries unusual methods to cure his insomnia; Christian and Kimber go into business together; Liz confronts Christian, and gives Kimber some unsolicited advice.