The book nears its release date; Masters takes on a high-profile patient; Virginia and Libby come to terms with their roles in Bill's life.
Masters and Johnson's book is released and, while reviews are positive, the public's response causes unease around the office.
Masters seeks advice on convincing Johnson to rededicate herself to the study; a familiar face returns to the clinic.
Virginia's parents arrive unannounced; Masters takes on a promising fertility patient.
Masters and Johnson take on a famous couple looking to revitalize its sex life; Tessa learns what Virginia's childhood must have been like.