The CSIs are called to three different crime scenes in one night that are seemingly unrelated, but each case's forensic evidence reveals a common link.
A man is found stabbed and handcuffed in a hotel room; a prank at the lab threatens an investigation and causes a rift in the team.
Christian searches for immortality; rejected by Ram, Kimber confronts Liz about her relationship with Christian.
An up-and-coming executive for a high-end clothing company is abducted after a rooftop party in Manhattan.