The Elric brothers take part in a manhunt for the dangerous Isaac the Freezer.
The past reveals the pain and desperation that drove the boys to break alchemy's greatest taboo, human transmutation, and their reasons for becoming dogs of the military.
The Elrics confront Father Cornello, who claims to work miracles, but the brothers suspect he is abusing a Philosopher's Stone to manipulate his flock.
The Elrics meet Shou Tucker, a leading researcher in the field of chimeras.
Edward and Alphonse are attacked by Scar, a mysterious killer with incredible powers, wanted for a string of gruesome murders.
The Elrics meet Dr. Marcoh, a State Alchemist running from past sins.
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