Tokyo was suddenly assaulted by the Great Collapse, causing everyone in the city to fall into a coma and enveloping Tokyo in a red mist. Five months later, university student Kamina Chihiro awakens, and curtains rise on the fierce Vermillion legend!

The man who was like a father to the solitary Chihiro transforms into a giant troll before his eyes. When Chihiro is struck by the creature's blade, his eyes glow a deep red and something begins to awaken inside him!

Only the chosen warriors known as Vessels of Heroic Blood are able to turn their own blood into weapons. First Chihiro, then his friend Kotetsu awaken as Vessels of Heroic Blood. But who keeps transforming innocent people into monsters?

Chihiro and his friends are bewildered by Dux's unexpected words. Believing he's destined to destroy everything in his life, Chihiro ignores the warnings of his friends and uses his immense power against Tokyo!

Chihiro can't stop thinking about what Yuri said to him. Does it have something to do with the lost memories of his childhood? The past Kakihara describes to Chihiro is a heartbreaking tragedy.

As a mysterious series of murders occur in Tokyo, Inuki goes missing. Chihiro desperately searches for Inuki, until Yuri appears before him. Meanwhile, Inuki continues to plunge towards destruction.