The Emergency Department deal with Sydney's night-life causing chaos. A young woman undergoes complicated heart surgery. An IC patient is violent towards staff.

Emergency nurses fight to revive a woman in cardiac arrest; a patient with terminal lung failure undergoes a risky lung transplant and a breech birth has midwife Lucy braced for resuscitation.

Emergency nurses fight to save a man whose gone into anaphylactic shock. Transplant nurse Rodrigo leads a mission across Australia to retrieve a donor heart, in order to save the life of its recipient.

Father-of-three Chris undergoes high risk brain surgery and needs a high level of care. Mental health nurse Kate is called into a police station to treat a confused woman at risk of self-harm.

Nurses treat a woman after a horse riding accident that could leave her paralysed. A nurse helps a man who has had a stroke.

The team must work fast when a young man's life is on the line as a lesion throws a potential lung transplant into jeopardy. Yoon and Darren race against time to save the life of a bariatric patient.