Invasive Burmese pythons are taking over the Florida Everglades and devouring everything in sight. The only way to stop them is to call in the nation's best swampers: King of the Swamp Troy Landry, his son Chase, legendary gator hunter Bruce Mitchell, and big fish wrangler Zak Bagby. Together with professional snake hunter Bill Booth, the men dive into the underbelly of the Everglades to capture and remove the sinister beasts.

One week into the hunt for invasive Burmese pythons, the swampers venture into the foreboding Everglades Triangle. Bruce, Zak and Bill hunt near a mysterious abandoned rocket silo, while Troy and Chase scoura cattle ranch for one of the world's deadliest snakes: the African Rock Python.

In the third week of fighting monster serpents, hunters face a terrifying reality: the invasion is bigger than they anticipated. With their backs against the wall, Troy, Chase and Bill call upon trackers and thermal drones to get a leg up on the snakes. Meanwhile, Bruce and Zak breakdown in the middle of a swamp that's rumored to be home to the largest serpent in the world--the green anaconda.

As the hunters face their final week in the Everglades, Troy and Chase protect a remote community from an aggressive gang of alligators. Then, the swampers join forces to track down a deadly hybrid python. Will they be able to stop the rise of the super snakes?

The Cajun Navy is back to fight the war against pythons invading the Everglades. King of the Swamp Troy Landry, along with his son Chase and snake expert Bill Booth, track serpents into a breeding ground known as Deer Haven. Meanwhile, veteran swamper Bruce Mitchell and invasive species hunter, Zak Catchem, take on the legendary Skunk Ape Alley, an area known for strange encounters and massive pythons.

As the hunting season heats up, Troy, Chase and Bill dive into deep water to catch pythons, but might be in over their heads. Meanwhile, Bruce and Zak fear they've bitten off more than they can chew when they venture into Viper Jungle, an area filled with venomous rattle Snakes and moccasins.