Murder’s a drag, when Jane and the CBI try to find the killer of a young man found burned to death outside a cabaret featuring female impersonators. During the investigation, they discover a list of suspects, all of whom bullied the victim.
A plumbing leak becomes a flood, causing chaos at Seattle Grace; the chief tries to implement new teaching policies; George tries to take his residency exam again; Derek hopes to move Meredith's roommates out of her house.
Bailey leads a team of doctors performing a string of surgeries in which each procedure depends on the one that preceded it; Derek gets all the credit for the brain tumor study he did with Meredith; Lexie tries hard to get George to notice her.
Bailey and Seattle Grace's new pediatric surgeon try to save the life of a longtime patient; the admission of a death row inmate angers Derek; Izzie tells Alex that she has been seeing Denny.
Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.