Meredith believes she may have erred during surgery and endangered her career; nothing goes as planned for Izzie, who tries to throw a party for her new boyfriend.
Sheldon's database invention puts him at odds with the university; the church takes issue with Meemaw's video store.
Katherine is unable to keep some of her secrets; Susan's young, attractive cousin reveals more than expected; a surprise wedding ceremony has its share of secrets.
Mama Solis' (Lupe Ontiveros) condition changes; Lynette befriends a deaf woman, Alisa, whose children also attend Barcliff.
Gabrielle plans a big party for Carlos, who is about to head off to jail; Rex is unhappy when George Williams (Roger Bart) resurfaces in Bree's life.