The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic.
An unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment; Amelia and Link try to have some fun as new parents.
Holmes and Watson get involved with nuclear security when they investigate the murder of a former Japanese crime syndicate gang member; Capt. Gregson is blindsided by a stunning personal confession from his daughter, a police sergeant.
Soon after Frank honors a detective with an award for his undercover work in Malaysia, the detective is captured by a Malaysian drug lord; Henry accompanies Jamie on a ride-along.
The governor asks McGarrett and Grover to serve a warrant to a young computer hacker (Nick Jonas) in order to protect national security.