Izzie ponders whether to have a risky procedure; a patient prompts Owen to reassess his place at Seattle Grace; George has stunning news for Bailey; the doctors of Seattle Grace band together to save the victim of a traffic accident.

Izzie's medical condition requires a difficult surgery; one of Owen's PTSD episodes causes Cristina to be injured.

While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.

Sam finds himself in the midst of a dangerous house call; Pete and Addison decide to take their relationship to the next level; Violet enters a friends-with-benefits pact with Cooper.

Charlotte asks Pete to treat her insomnia; Naomi has her first date since college; a patient wants Addison and Naomi to keep information about her fertility from her husband.