An explosion at a wedding ceremony sends a stream of partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries; Iggy helps a young girl out of a catatonic state.
Max struggles with a new fiscal reality at the hospital. Dr. Sharpe's on a mission to provide follow-up cancer screenings for patients before it's too late. Bloom grapples with Dr. Shinwari's new overnight schedule. Reynolds has an interesting discussion with Dr. Malvo.
When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.
When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain's doctors to put aside their personal issues to try and save his life.
Max and Luna make friends in an unexpected place as he struggles with the realities of being a single father. Meanwhile, Kapoor takes a big step in order to help his family.