Jones realizes that humanity's true enemy is time-travel itself, and decides to send Railly back to 2020 to undo everything; Cole and Railly discover an anomaly during their quest.
Jennifer Goines forms The Hyenas to take on the 12 Monkeys' organization, and with the help of Cole, they discover a plan to acquire the virus.
Cole and Railly adjust to the past, but a mysterious women with apocalyptic visions gets them to do the unthinkable to save the world.
Cole and Railly attempt to stop the final paradox; Ramse, Jennifer and Deacon struggle to survive the apocalypse in an effort to find the Witness.
As the temporal facility gets closer to destruction, Cole goes to 1957 to save humanity while everyone else looks for Titan, the stronghold of the Witness.
