Masters must decide if she wants to be a surgeon or officially join House's team; a 16-year-old collapses days before embarking on a sailing tour of the globe.
Goodwin is forced by the hospital board to implement new guidelines that cause headaches for the doctors; Dr. Rhodes and Ava continue to compete in the operating room; Dr. Charles and Dr. Reese are surprised by a patient's theory about his sickness.
The Jeffersonian team investigates the death of a young boy whose soul remains very much alive. When psychic Avalon Harmonia (guest star Lauper) attempts to help the deceased’s spirit cross over, each member of the team begins to question his or her own beliefs about life after death.