Sam and Dean begin to explore what Jack is capable of doing with his powers; an unexpected visit from Donatello alerts the brothers to the fact that Jack will need more protection than they can provide.
Sam and Dean's quest to save their family leads them to a Men of Letters bunker from the 1920s and a hungry god from another dimension; Ketch makes a shocking decision about Gabriel after an encounter with Asmodeus.
As Sam and Dean continue their search for Jack, they stumble across a familiar foe; Lucifer manages to escape Michael's grasp and finds an unlikely and mostly unwilling ally.
Sam, Dean and Castiel search for Lucifer, who is negotiating an unlikely deal with a local faith healer named Sister Jo; Asmodeus gets closer to finding Jack.
When the team discovers an illegal weapons dealer has sold stock to someone targeting a high-level politician, they rush to stop a deadly ambush.