Tony and Uncle Junior are about to get involved in a family power struggle; Tony's mother agrees to live in a retirement community.
When a series of deaths occurs at Seattle Grace, the uncanny events bring out the doctors' superstitious sides and make Izzie nervous about Denny's surgery.
Meredith and Cristina lie to each other about their relationships; George must discharge an elderly patient who is no longer sick but refuses to leave the hospital.
A traumatic car accident fills the ER; Cristina has a crisis of conscience about her deceptive teamwork with Burke; Izzie pushes the boundaries of probation.
The nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves; an elderly patient's friends (June Lockhart, Betty Garrett and Rae Allen) bring Meredith's mistake to light.