Gloria invites the whole family on a getaway to Hawaii for Jay's birthday.
House and the team treat an agoraphobic who adamantly refuses to leave his home and get treatment at the hospital; Chase and Cameron try to work through some kinks in their relationship; House deals with an itch he can't seem to scratch.
Agent Prentiss has a personal connection to one of the victims in a series of deaths with religious overtones.
During a 36-hour shift, the doctors are faced with a distraught woman whose sons were in a devastating car accident; Mario makes Angus perform an unnecessary operation.