News anchor, Jodi Huisentruit, vanishes before her morning newscast in Iowa; for the next 24 years her family and friends are tormented with theories of her demise; diving into the cold case to find out the truth about Jodi.

The mysterious disappearance of Korrina Malinoski, and daughter Annette, from their South Carolina home, has continued to baffle family and police for the past 30 years; Payne and team attempt to reunite a family in the process.

Krystal Reisinger, 29, goes to Colorado on a spiritual journey and vanishes; foul play is suspected, but there are few clues.

Molly Miller, 17, and Colt Haynes, 21, vanish after a high-speed chase with police; Payne learns the suspect is related to someone in law enforcement who was charged with corruption and heads to Oklahoma with his team to unravel the mystery.

In 2006, business executive Jennifer Kesse, 27, goes missing from Orlando, Fla.; Payne Lindsey and his team work with her family in search of answers.