James Frain

Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.

While a jury deliberates the guilt or innocence of a defendant on trial for murder, Jane tries to prove she has been wrongfully accused before time runs out. Meanwhile, Summer may have gone too far when she helps Cho make a case against a suspect. Numb3rs Diane Farr guest stars as the best friend of the accused.

Lightman is confronted by a familiar face who wants a debt repayment. Meanwhile, the team's services are required to prevent a shooting at a school.

When Howard Stark finds himself being framed, he reaches out to Peggy to help him clear his name, empowering his butler to help her as needed.

Sarah pursues the missing Helena who is held in a faraway compound. Meanwhile, Cosima appears to be rebounding from her illness, while Alison and Donnie face newfound financial woes. But when the menace of Castor rears its head once more, Sarah and her entire family must come together to survive.