A dangerous situation leaves the doctors fighting to stay alive while trying to save their peers; Ben and Bailey make a decision; Teddy gets a tempting offer; Richard plans a dinner for the residents.
In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.
Madison comes face to face with a terrifying new discovery and Nick detects a new threat descending upon the dam.
Baby Josh recovers from the rapid detox treatment - but Dr Ross may lose his job anyway; Dr Corday's problems with Romano reach breaking point and Nurse Hathaway makes a gruesome discovery.
As Boyd (Walton Goggins) and Arlo (Raymond J. Barry) negotiate a truce in their war with the Bennetts, Loretta McCready (Kaitlyn Dever) has taken her foster father’s gun and is en route back to Harlan. And as the feud between the Crowder and the Bennett crime families reaches a bloody climax, Loretta demands that Mags tell her the truth about her father’s death.