Upon his return to New York, Suresh finds a previously undiscovered painting that foretells the death of someone close to him, Claire and H.R.G. pursue their own agendas, and Maya uses her deadly abilities to free Alejandro from a Mexican prison.
Matt investigates the death of a hero, another hero is attacked by a new sinister force, and Niki, Micah and the Haitian return.
In Ireland, a lost hero discovers that a mysterious woman is willing to kill to find him, Matt and an unexpected ally fly to Philadelphia to hunt down the "boogeyman", and Monica tries to come to terms with her new abilities.
Peter tries to destroy the virus he believes will kill most of the world's population, Niki has bad news for Micah, Hiro goes after his father's killer, and Matt uses his abilities to track down the last person in the Company photo.
A sudden manifestation of one of Peter's forgotten abilities throws him and Caitlin into a crisis situation, heroes band together to fend off the "nightmare man", West learns who kidnapped him as a child, and Hiro's journey takes a dramatic turn.