In 1964, the notorious serial killer Bloody Face is committed to the sanitarium Briarcliff Manor. Reporter Lana Walker arrives to interview the asylum's head nun, Sister Jude, but is secretly hoping for a story on Bloody Face.
As a Nor'easter storm approaches, a strangely transformed Sister Mary Eunice sows discontent, and worse. As Dr Arden's strange experiments on Kit continue, another escape attempt is hatched, and Dr Thresdon makes a terrible discovery.
A sinister, murderous child is brought to Briarcliff. Meanwhile, Lana struggles to escape from her new predicament, we learn the history of Dr Arden and Monsignor Timothy's collaboration, and we delve in to the childhoods of Dr Thredson and Sister Mary Eunice.
The Monsignor resolves to help Sister Mary Eunice battle the Devil within, while the now-powerless Jude is punished severely by the possessed nun. As Dr Arden brings his experiments to a shocking end, Lana and Kit find themselves at Thredson's mercy once more.
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