Dr Rhodes is tasked with delivering some devastating news. April suffers an accident and Dr Halstead presses her into seeking treatment.
The team treats a 9/11 hero in need of new lungs. Dr Choi deals with a difficult parent. There's friction between Dr Halstead and Dr Manning.
Family secrets bubble up to the surface when Maggie's sibling arrives back in town. Dr Manning works on a case that is getting lost in translation.
Dr Charles' daughter joins the epidemiology department and is immediately put to task when cases of a rare infection are discovered.
Will confronts a moral decision when his former teacher faces a life-threatening disease, Rhodes disagrees with the father of a young patient about a risky procedure and an unusual case causes Sarah to recall Jason Wheeler's suicide.