Dr Rhodes is tasked with delivering some devastating news. April suffers an accident and Dr Halstead presses her into seeking treatment.
Family secrets bubble up to the surface when Maggie's sibling arrives back in town. Dr Manning works on a case that is getting lost in translation.
Dr Charles' daughter joins the epidemiology department and is immediately put to task when cases of a rare infection are discovered.
Dr Rhodes persuades Dr Latham to accompany him on a medical trip out of town. Meanwhile, an 8-year-old cancer patient wants to give up his battle.
Robin is admitted back into the hospital with more complications. Rhodes faces competition from a new hotshot doctor.