Dr Rhodes is tasked with delivering some devastating news. April suffers an accident and Dr Halstead presses her into seeking treatment.
The team treats a 9/11 hero in need of new lungs. Dr Choi deals with a difficult parent. There's friction between Dr Halstead and Dr Manning.
Dr Charles faces a difficult case involving a patient who wants to remove his own arm, while Halstead and Goodwin try to help a grieving widower.
Two of the team disagree about how to treat a patient with heart problems and Choi comes to the aid of an injured hoarder while out on paramedic duty.
Family secrets bubble up to the surface when Maggie's sibling arrives back in town. Dr Manning works on a case that is getting lost in translation.