The team tracks a serial rapist who attacked women at religious schools before taking a six week break. Now he has returned, targeting a different demographic group.
A sixteen-year-old Hurricane Katrina victim suffering from hallucinations is brought to House by an old friend who recently found out the girl is his daughter.
Lynette and Tom feel that it's time for twins Porter and Preston to move out on their own and learn how to become responsible adults, but the boys end up moving out to a pad that's a little too close to home.
When evidence of the death of a four-year-old girl washes up on the New Jersey shore, Rush and the team reopen a 1965 case.
Jonas tries to rescue a group of missionaries from Indonesia, but soon finds himself outgunned. Meanwhile Molly, Kim and Tiffy prepare to host a visiting senator.