After Abby McCarthy, author of self-help books and guru to people with family issues, states that she and her husband have separated, her career screeches to a halt. The revelation puts America's once-favourite girlfriend in free fall. Acclimating to being single in her 40s, she turns to friends for advice: Entertainment lawyer Lyla does constant battle with her ex, and entrepreneur Phoebe has an odd relationship with hers. For the divorce, Abby hires Delia, an associate of Lyla's. The `Girlfriends' Guide' book series inspired the dramedy.
