Louis Theroux travels to San Francisco where a group of pioneering medical professionals help children who say they were born in the wrong body transition from boy to girl or girl to boy at ever younger ages. Louis meets children who have been diagnosed with gender dysphoria. Louis is told that children as young as three can show signs of rejecting the gender they were assigned at birth, leaving parents with a difficult dilemma - do they start transitioning a child who is still developing their own identity or do they wait and leave the change to the grown up child?