Meredith becomes disenchanted with her ignorance of parts of Derek's life; Alex treats a patient whose religious beliefs jeopardize her chances for recovery; a 40-year-old pregnant woman with cancer disagrees with Cristina's advice.
Naomi seeks Fife's help with William's experimental treatment for ALS; Violet and Amelia treat a woman with a brain tumor; Sheldon goes after Charlotte's affections.
Despite their humiliating defeat Buffy is convinced the vineyard is important, but when she tries to rally the girls for a second fight she finds her leadership challenged.
Buffy confronts Caleb not knowing he has been endowed with the powerful essence of The First, yet as Caleb prepares to deliver a death blow an old friend comes to Buffy’s aid.
While Faith attempts to step into the leadership role Buffy heads to the vineyard alone to confront Caleb – and finds a formidable weapon in an underground chamber.