Dr. Sturgis recommends Sheldon and Missy for a university research study on twins and Mary is unhappy when the test results go to Sheldon’s head.
Charlie tries to sweet talk Judith's divorcee support-group into letting Jake continue to spend weekends at his place.
All reassess their personal lives after witnessing a chance reunion between two long-lost lovers in the emergency room; Karev treats a troubled teen (Demi Lovato); Meredith shares her suspicions with Cristina.
When a modern-day prospector is found dead near a mining site and Lisbon is injured during the initial stages of the investigation, Agent Hightower joins Patrick Jane in the field for the first time.
Sue auditions for show choir; Brick asks Frankie to come to his class presentation dressed in a costume; Frankie thinks she has finally sold a car.