While tasked with rescuing a group of American students held hostage in Mumbai, Bravo Team suffers life-threatening injuries
Ray enlists Lena and Daryll's help to cement Hector's rematch with Whittaker; an angry neighbor confronts the Donovans; Teresa's depression takes a turn.
Jennifer Goines forms The Hyenas to take on the 12 Monkeys' organization, and with the help of Cole, they discover a plan to acquire the virus.
The team has one final chance to return to the timeline, but their actions may have deadly consequences.
Coulson and the team find themselves stranded on a mysterious ship in outer space.