Meredith, Richard and Alex must deal with the consequences after Bailey fires them for insurance fraud; after disappearing in the fog, Jackson helps a man in a dangerous situation; Tom gets new responsibilities at the hospital.
The doctors operate on a man who crashed into Maggie's car; Owen, back from paternity leave, struggles with Tom's new position; Meredith's recent firing doesn't stop her from diagnosing those around her; Richard and Alex start anew and it's not easy.
Meredith tiptoes the line of protocol as she helps Jo with a difficult procedure from afar; the sisters of a patient who is brain dead after a fall into a construction site must decide whether or not to keep her alive.
Jackson must focus on the groundbreaking surgery he has scheduled with Catherine and Richard; Jo assists Bailey with a patient who used to be an astronaut.
As fog begins to cover Seattle, the doctors must navigate through personal complications; Meredith and Alex attempt to save Gus; Levi talks some sense into a struggling Nico.