The BAU goes on a manhunt for a group of suspects with a pack mentality who kill for the thrill of it.
Crowley notices Dean's increasing level of aggression; a vengeful man named Cole captures and tortures Sam.
Sam ignores Dean's directive and continues to search for a cure; a new murder case brings the brothers in contact with Cole -- who ends up being infected by a Khan worm that turns men into murderers.
Now in Lindsey's custody Sydney is imprisoned and tortured at Camp Williams a secret NSC detention facility.