Dr. Manning struggles with the aftermath of a head injury; Dr. Manning and Dr. Halstead deal with a teenage patient and her overbearing older husband; Dr. Rhodes learns alarming information about the woman he went on a date with.
While searching for Fredwynn at the shareholders' meeting, the gang has their first encounter with Octavio; Janice explores her past.
Fredwynn takes matters into his own hands, but he needs his teammates to move on; he searches for the next clue and asks the gang for help; they take it too far in their search for answers leading them somewhere unexpected.
With time running out, the gang splits up in an effort to find Clara; Simone and Janice follow her artwork, while Fredwynn and Peter link the game to a large corporation.