The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit, as Izzie plans a big dinner at Meredith's -- but it remains to be seen who among the invited guests will actually show up. Meanwhile, George endures the O'Malley tradition of hunting turkeys with his less-than-sophisticated family, and Meredith treats a patient who's been in a vegetative state for 16 years.
The BAU team springs into action when a school bus full of children goes missing near Washington, D.C.
A group of teenagers are driving on the freeway when a skull smashes through their windshield. At the Jeffersonian lab, Brennan tests out a young forensic anthropologist to replace Zack, who has left for Iraq, and she and Cam examine the skull in question. They find it has marks made by human teeth, suggesting cannibalism. The team identifies the victim, a known violin protégé who disappeared after a concert. On a quest to find out what happened to him, Brennan and Booth go into the field. A trail of suspects leads them to a strange cannibalistic society, and the team must string together a gruesome and cryptic series of crimes – provided that Brennan and Booth can survive the newfound tension between them. Meanwhile, Cam suggests that Angela hire a private investigator to track down her ex-husband so she can annul her previous marriage and marry Hodgins, a task easier said than done.
Lois heads to Canada to visit relatives, and Hal takes part in a father-son race with Dewey, despite being temporarily blind.
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