The eldest daughter of a family involved in a car crash must make a difficult decision; Teddy asks Cristina to help with an O.R. patient; Lexie works with Mark's new girlfriend during a surgery.
The team is called to Louisville to help local authorities determine what caused a disturbed man to have a psychotic breakdown at a pharmacy and murder several customers.
After being terminated from Chastain, Conrad distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system.
Black Bolt and Medusa are forced to pin their hopes on Louise as they flee Auran's forces. Maximus makes a game-changing move.
Tragedy strikes the Royal Family as Gorgon and Karnak take on Auran and her inhuman army with deadly consequences.