Kai Lennox

Derek and Addison Shepherd's professional relationship is challenged when their closest friends come to Seattle Grace seeking a radical, preemptive operation to avoid breast and ovarian cancer. Meanwhile, George can't understand why a patient who fell five stories doesn't seem happy to have survived; an elderly gentleman makes a difficult decision upon learning that his wife has only a few months to live; Cristina and Burke try to have a "normal" date, and Chief Webber is disappointed by Bailey's fellowship decision -- until he learns her reasons.

House and his team treat an underage runaway girl who refuses to identify her parents. Meanwhile, Taub tries to find common ground with his infant daughters, Foreman's affair takes a surprising turn, and House treats two brothers who engage in Civil War reenactments.

An out-of-this-world case brings Brennan and Booth to New Mexico where they investigate human remains with extraterrestrial attributes. The victim is identified as a local UFO fanatic, known around town for her relentless search for alien life forms and whose latest “evidence” leads even Brennan and Booth to re-think outside existence. Meanwhile, a local sheriff refuses to release the bones, forcing the team at the Jeffersonian to work via satellite, and Angela and Jeffersonian intern Wendell (guest star Michael Grant Terry) come clean about their relationship.

A petty officer is killed in an apparent road-rage incident. As the team investigates, they discover he was involved in an underground fight club and now they must find out if his involvement led to his death.

Castle is captured and forced to work with strangers to solve deranged puzzles and mind games, while Beckett and the 12th precinct must race against time to rescue Castle and catch a killer.