Owen becomes invested in a patient when he realizes she may have served in the military, April's mother pays her daughter a visit and bonds with Jackson, and Derek plans a family dinner. Meanwhile, a patient's diagnosis causes Bailey to reconsider her own health issues and Dr. Herman drops a bombshell on Arizona.
When Christy gets promoted to manager of the restaurant, she discovers that being the boss comes with its own set of problems. Meanwhile, Bonnie encounters a nemesis in the building who wants to have her fired.
The ER is quarantined when a viral outbreak jeopardises the lives of the doctors and patients; a young girl whom Leanne bonded with a year ago when she lost her father returns to Angels Memorial.
Besieged by Marie Laveau’s army, Zoe unleashes a new power. Fiona and Myrtle clash over control of the Coven. Madame LaLaurie is confronted by old ghosts.
A citywide blackout leaves the hospital without power or back-up generators. Elliot and Heather are trapped in an elevator with a woman in labour.